<b>Results:</b> Importantly, the analysis of the functional pathways showed that all the genes are mapped to core dysregulated host pathways in active TB: antigen presentation (<i>TAP2</i>), lipid trafficking (<i>SORT1</i>), interferon response (<i>WARS</i>), and inflammasome signaling (<i>ANKRD22</i>). This evidence concerns the gene TAP2 and tuberculosis.