We investigated if breast adipose tissue from healthy women, BRCA1/2 mutation carriers and BC patients, can stimulate BC cell line migration and activation.<h4>Methods</h4>adipose tissue conditioned medium (ATCM), was prepared from breast adipose tissue from healthy subjects (naïve; group 1 (<i>n</i> = 20)), BRCA1/2 mutation carriers (group 2 (<i>n</i> = 22)) and BC patients (group 3 (<i>n</i> = 38)). The gene discussed is BRCA1; the disease is breast cancer.