The CX3CR1<sup>+</sup>KLRB1<sup>dim</sup> subset represents a candidate prognostic biomarker in HPV<sup>+</sup> disease, and the CLEC2-KLRB1 axis is a targetable immune evasion mechanism in HPV<sup>-</sup> HNSCC. The gene discussed is CLEC1B; the disease is head and neck squamous cell carcinoma.