<b>Methods</b>: In this study, we demonstrate the utility of multi-omic integration of global transcriptomic, proteomic, and phosphoproteomic profiles of samples from patients diagnosed with either of two B-ALL subtypes-Ph-like (<i>BCR::ABL1</i>-like) and <i>ETV6::RUNX1</i>. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.