<b>Conclusions</b>: These findings suggest that ADT restricts cancer cell proliferation and migration through chromatin remodeling mediated by the motif CGTTTCCGGT and the downregulation of <i>C11orf54</i>, identifying <i>C11orf54</i> as a potential target for enhancing the efficacy of arginine deprivation therapy in cancer cells. Here, BKGD is linked to cancer.