Cytokine secretion was analyzed using the bead-based LEGENDplexTM assay.<h4>Results</h4>Non-toxic concentrations of the ivy-, thyme- or Pelargonium - containing medications, but not the medication containing cineole, significantly reduced the secretion of inflammatory cytokines and chemokines after the stimulation of TLR7 and TLR8 in A549 and NuLi-1 cells.<h4>Conclusion</h4>Medications derived from ivy, thyme and Pelargonium extracts exhibit anti-inflammatory properties in a model mimicking viral infection in human lung epithelial cells. This evidence concerns the gene TLR8 and viral infectious disease.