Primary inverse-variance weighted analysis was adjusted for multiple testing and validated via weighted median and MR-Egger sensitivity analyses.<h4>Results</h4>Genetically proxied GLP1R activation was associated with lower risk of overall HF [OR 0.96 (95% CI 0.95-0.98), P & .0002], ni-HF [0.94 (0.91-0.96), P & .0001], and ni-HFpEF [0.82 (0.74-0.90), P & .0001] per 0.1 log-odds lower T2DM liability. This evidence concerns the gene GLP1R and hydrops fetalis.