HLA-DRB1 and myeloid sarcoma: Participants who smoked, were exposed to dust, and carried the <i>HLA-DRB1*15:01</i> allele had an 11-fold increased rate of MS (OR 11.1, 95% CI 5.7-21.9), compared with those without any of these risk factors.<h4>Discussion</h4>Occupational dust exposure was associated with increased rate of MS, particularly in combination with smoking and HLA-DRB1*15:01, suggesting joint effects of occupational, environmental, and genetic risk factors.