The patients in the trial group performed significantly better than the control group in all outcome indicators such as MMS (P < .01), Penetration-Aspiration Scale (P < .01), spontaneous swallowing frequency (P < .01), Clinical Pulmonary Infection Score (P < .01), hemoglobin (P < .05), and prealbumin (P < .0001), with statistical significance.<h4>Conclusion</h4>Modified air-pulse stimulation is an effective therapy for improving swallowing function in tracheotomized stroke patients with dysphagia. This evidence concerns the gene TTR and Stroke.