PON1 and theileriasis: Combination therapy significantly reduced parasitemia (3.76% to 0.18%, p < 0.001), improved hematological, liver, and metabolic indices, decreased APPs, and increased paraoxonase-1 activity, compared to BVQ alone.<h4>In conclusion</h4>Bovine theileriosis is highly prevalent in Dakahlia and Damietta, particularly in middle-aged, pregnant, and tick-infested cattle during the summer.