HCRT and obesity due to melanocortin 4 receptor deficiency: Elevated levels of neuropeptide Y and orexin were independent risk factors for obesity (OR = 1.123, 95% CI = 1.023-1.232, p = 0.015; OR = 4.004, 95% CI = 1.174-13.656, p = 0.027), while increase in oxytocin level was an independent protective factor (OR = 0.833; 95% CI = 0.697-0.995; p = 0.044).<h4>Conclusions</h4>Among women of childbearing age, fluctuations in multiple endocrine hormones and hypothalamic neuropeptides within the normal range play a crucial role in regulating body weight and plasma lipids.