A total of 10 features with the highest predictive value were selected using the RFE method, including troponin T, platelet distribution width, neutrophil count, red blood cell distribution width, fibrinogen, prothrombin time activity, aspartate transaminase, urea, low-density lipoprotein cholesterol, and creatinine.<h4>Conclusion</h4>Age, SOFA score, coagulation dysfunction, and metabolic abnormalities are important prognostic risk factors for participants with malignant tumors complicated by sepsis. Here, F2 is linked to Sepsis.