IGHE and schistosomiasis: Mechanistically, repeated PZQ treatment of SAC was associated with heightened arginine/proline metabolism that translated into higher protective IgE levels (p = 0.002) and increased type-2 cytokine production.<h4>Conclusion</h4>Our study highlights a previously underappreciated advantage of sustained PZQ treatment in SAC from schistosomiasis-endemic areas.