Furthermore, we constructed a protein-protein interaction (PPI) network and performed functional annotations involving EIF3H.<h4>Conclusion</h4>Our findings indicate that ncRNA-driven overexpression of EIF3H is associated with poor prognosis and tumor immune cell infiltration in PAAD, suggesting that the AC005034.3/hsa-miR-126-5p/EIF3H axis may serve as a promising prognostic biomarker and therapeutic target in PAAD. The gene discussed is EIF3H; the disease is pancreatic adenocarcinoma.