The coordinated upregulation of integrins, other adhesion molecules (CD44, NCAM1, VCAM), ECM (FN1, collagens) and their regulators (SPP1, TIMP2,3) in response to the culture conditions indicate a complex reprogramming of adhesion networks that can facilitate different steps of ovarian cancer progression and dissemination. Here, FN1 is linked to ovarian carcinoma.