In this study, we investigated the diagnostic value of VAP using serum and bronchoalveolar lavage fluid (BALF) levels of presepsin, procalcitonin (PCT), and lipopolysaccharide-binding protein (LBP).<h4>Methods</h4>The serum and BALF samples were collected from 300 consecutive mechanically ventilated patients with a clinical suspicion of VAP by bronchoscopy. The gene discussed is LBP; the disease is ventilator-associated pneumonia.