We tested whether p53 deficiency is associated with coordinated mTORC1 activation, autophagy attenuation, and immune-cold remodeling across multi-omics datasets.<h4>Methods</h4>We analyzed GSE146009 (paired tumor-normal RNA-seq pairs), TCGA-COAD/READ (n = 647, mutation annotated), GSE108989 (11,138 tumor-infiltrating T cells), and CPTAC colon proteome/phosphoproteome cohorts. Here, TP53 is linked to neoplasm.