We sought to evaluate tissue and serum ACE2 profiles in IBD and healthy controls and evaluate alterations related to disease activity and medical therapy.<h4>Methods</h4>Circulating sACE2 and intestinal tissue ACE2 was evaluated respectively in serum samples and endoscopic biopsies from patients with IBD and healthy controls in addition to murine DSS induced colitis.<h4>Results</h4>91 IBD (UC/n=41; CD n=50) and 55 controls were analyzed. The gene discussed is ACE2; the disease is inflammatory bowel disease.