Most strikingly, MJQP restored the abundance of <i>Lachnospiraceae, Lactobacillus</i> and <i>Clostridium</i>, and increased the gut microbiota derived tryptophan metabolites Indole-3-acetic acid (IAA) and Indole-3-propionic acid (IPA), which serve as endogenous AhR ligands to enhance AhR signaling.<h4>Conclusion</h4>MJQP repaired the damaged intestinal barrier to facilitate the resolution of chronic colitis by modulating AhR-mediated ILC2/ILC3 balance through gut microbiota-related tryptophan metabolism. Here, AHR is linked to Chronic colitis.