In contrast, sociodemographic correlates that distinguished PN from AD were not consistently different between IgE-defined PN subgroups.<h4>Conclusions</h4>In Chinese adults, PN exhibits clinical heterogeneity with two distinct patterns: one characterized by variability in type 2 immunity-associated and atopic features, and the other by a substantial burden of specific sociodemographic and metabolic comorbidities. Here, IGHE is linked to Alzheimer disease.