Moreover, the injury severity score (ISS), Acute Physiology and Chronic Health Evaluation (APACHE II), complications during hospitalisation (infection, MODS, etc.)and 28-day survival of the patients were recorded.<h4>Results</h4>The concentrations of serum HMGB1 and sTREM-1 in the trauma group were significantly greater than those in the control group (P&lt; 0.01) and increased with increasing ISS. Here, HMGB1 is linked to infection.