SGMS2 and idiopathic juvenile osteoporosis: All eleven exons and exon-intron boundaries of <i>SGMS2</i> were sequenced.<h4>Results</h4>In a cohort of 44 patients (42 females and two males, median age at the time of recruitment 60 years, range 25-76 years), we identified one rare heterozygous missense variant (c.715T>C, p.Phe239Leu) and three intronic variants with unknown functional consequences; no pathogenic or likely pathogenic variants were found.<h4>Conclusion</h4>Our results suggest that pathogenic variants in <i>SGMS2</i> are not a common cause of early-onset idiopathic osteoporosis in Finnish patients.