Secondary endpoints included NRS, Cox Menstrual Symptom Scale (CMSS), Traditional Chinese Medicine (TCM) syndrome score, serum Prostaglandin F2α (PGF2α) and Prostaglandin E2 (PGE2), rescue ibuprofen use, and safety outcomes (local skin reactions and serum alanine aminotransferase [ALT]).<h4>Results</h4>Of 110 randomized participants, 102 participants completed the end-of-treatment assessment. This evidence concerns the gene GPT and Down syndrome.