More importantly, examination of kidney biopsies from class III/IV LN patients demonstrated the presence of EBV-dUTPase in infiltrating plasma-cell aggregates near glomeruli, where neighboring cells with increased TLR-2 and IL-17 expression were observed, suggesting EBV-dUTPase may exacerbate the immunopathologies in some LN patients. This evidence concerns the gene IL17A and lobular neoplasia.