IL17A and hyperinsulinemic hypoglycemia, familial, 4: <h4>Objective</h4>To investigate the mechanism of Th17 cells in immunomodulation during periodontitis and develop a localized drug delivery system based on glycolysis inhibition for safer and more effective therapeutic interventions.<h4>Methods</h4>Periodontitis models were established via the use of IL17A-KO mice to evaluate the impact of Th17-related cytokine deficiency on pathological progression.