MPO and sickle cell disease: The reported SMDs using a common-effect model were 1.15 [0.96; 1.34] (p <0.01) for Lactate Dehydrogenase (LDH), 1.03 [0.48; 1.53] (p <0.01) for Myeloperoxidase (MPO), and 1.13 [0.96; 1.29] (p <0.01) for Malondialdehyde (MDA), reflecting the strong influence of sickle cell disease on hemolysis and the production of lipid peroxidation markers compared with normal controls.