Moreover, administration of ferroptosis inhibitor liproxstatin-1 and autophagy inhibitor methyladenine (3-MA) ameliorated colonic tissue damage in the animal model of colitis, reducing the disease activity index (DAI), colon macroscopic damage index (CMDI), and pathological score, as well as the serum contents of mucosal permeability markers diamine oxidase (DAO) and D-lactic acid (D-LA) (all P<0.05). Here, AOC1 is linked to colitis.