In vitro mechanical stretch induced marked increases in Akt (CKD: +5651%, p = 0.012; healthy control: +3437%, p = 0.028) and p70S6K phosphorylation immediately post-stretch (CKD: +1076%, p = 0.014; healthy control: +712%, p = 0.038). This evidence concerns the gene AKT1 and chronic kidney disease.