High CA19-9 staining was associated with advanced pT-stage, pN1, L1 (p < 0.0001 each), V1 (p = 0.0239), mismatch repair protein deficiency (p = 0.0067), and BRAF V600E mutation (p = 0.0005) in colorectal adenocarcinoma. The gene discussed is BRAF; the disease is colorectal adenocarcinoma.