SLC7A11, a key player in cellular antioxidant defense and ferroptosis regulation, has unexplored functions in diabetic cerebral ischemia/reperfusion.<h4>Methods</h4>In this study, we employed leptin receptor deficient (db/db) mice and wild-type (WT) littermates to model cerebral ischemic stroke. Here, SLC7A11 is linked to brain ischemia.