TNFRSF11A and cartilage-hair hypoplasia: In parallel, we have identified different RANK gene variants in patients with congenital hypogonadotropic hypogonadism (CHH), a human syndrome that shares several phenotypic characteristics with full-body and microglia-specific Rank-deficient mouse models, reinforcing the importance of Rank signaling within microglia in HPG regulation, pubertal onset, and fertility.