SWAP-70 shRNA-treated mice showed significantly higher lymph node CD19+CXCR5+CD21+ follicular B-cell ratios than other groups, whereas ratios of other effector B-cell and T-cell subsets were comparable among groups.<h4>Conclusion</h4>SWAP-70 appears to have an autoimmunity-suppressing effect in the PLP-EAE model, likely mediated by inhibiting follicular B cells. Here, CR2 is linked to Autoimmunity.