MAPT and Alzheimer disease: Building on top of previously reported work, we used herpes simplex virus 1 (HSV-1) infection in 2D dissociated cells from human cerebral organoids (dcOrgs) to recapitulate AD-associated molecular readouts, such as high co-abundance of intracellular beta amyloid (Aβ) and phosphorylated tau (pTau) with HSV-1.