Notch signalling and altered expression of its ligand Jagged1 (JAG1) have been implicated in CRC progression, yet their relevance in bevacizumab-treated patients and their regulation by 5-FU remain unclear.<h4>Methods</h4>JAG1 protein levels were quantified in tumour samples from patients with metastatic CRC (<i>n </i>= 60) by using enzyme-linked immunosorbent assay and correlated with clinical outcomes. This evidence concerns the gene JAG1 and neoplasm.