<h4>Objective</h4>To describe the impact of social determinants of health (SDOH) on visual acuity (VA) at presentation among patients with retinal vein occlusion (RVO).<h4>Design</h4>A retrospective single-center cohort study.<h4>Subjects</h4>All patients with RVO (central and branch retinal vein occlusion [CRVO and BRVO]) who received their first intravitreal anti-VEGF injection between January 2015 and March 2025 at a single center.<h4>Methods</h4>Sociodemographic factors including age, gender, race, and ethnicity were recorded. The gene discussed is VEGFA; the disease is retinal vein occlusion.