ACE and diabetes mellitus: The 3-item model identified mitral annular systolic velocity, systolic and diastolic pulmonary artery pressure, triglycerides, left atrial volume index, diabetes, and treatment with furosemide or angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers as key predictors of multi-organ congestion (area under the curve = 0.79).<h4>Conclusion</h4>AI-assisted integration of multi-organ US characterizes congestion as a multidimensional phenotype beyond conventional clinical assessment and biomarkers across the HF spectrum.