In conclusion, this case demonstrates that refractory post-procedural bleeding in neonates, despite normal routine labs, necessitates prompt investigation for a qualitative platelet disorder such as GT or other inherited thrombocytopathies. In regions with high consanguinity, where local registries report a markedly elevated prevalence, systematic preoperative screening for family bleeding history is a critical preventive measure. Here, ITGA2B is linked to blood platelet disease.