<h4>Background</h4>Detection of metastatic disease is important to inform prostate cancer management.<h4>Objectives</h4>Evaluate local and distant staging by initial <sup>18</sup>F-PSMA-1007 PET in primary and secondary prostate cancer.<h4>Design setting and participants</h4>We retrospectively identified a consecutive series of <sup>18</sup>F-PSMA-1007 PET scans from the date of introduction of <sup>18</sup>F-PSMA-1007 PET in September 2019 until April 2022 at a single UK tertiary referral center. The gene discussed is FOLH1; the disease is prostate cancer.