Serum amyloid A1 (SAA1), an acute phase protein, and insulin, a hormone linked to metabolic and inflammatory pathways, may play significant roles in acne pathogenesis.<h4>Objective</h4>This study aimed to evaluate SAA1 and insulin levels in patients with acne vulgaris and to investigate their relationship with disease severity and scar formation.<h4>Methods</h4>A total of 72 acne vulgaris patients [13 males, 59 females; median age 22 (19-34) years] and 66 age-similar healthy controls [27 males, 39 females; median age 22 (18-38) years] were included. This evidence concerns the gene INS and acne.