HGC associated with U-CLL (81%, p < 0.001), TP53-aberration (36%, p < 0.001), short TL (TL-S; 61%, p < 0.05), del13q (50%, p < 0.001) and del11q (22%, p < 0.05). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.