Furthermore, changes in the transcriptional expression of C-Man-Trp metabolism-related genes, C-mannosyltransferases (Dpy19l1 and Dpy19l3), and thrombospondin type I repeat superfamily genes (Thbs1, Spon1, and cellular communication network factor 1) were noted in tumor-associated cells and tissues. Here, THBS1 is linked to neoplasm.