We used immunohistochemical DAB method to detect and found that the content of GSK3B in laryngeal cancer was significantly higher than that in vocal cord polyps (p < 0.05), and the content of GSK3B also in pharyngeal cancer was significantly higher than that in vocal cord polyps (p < 0.05).<h4>Conclusion</h4>Prognostic model constructed based on tumor module-associated differential autophagy genes in HNSC holds prognostic value.<h4>Level of evidence</h4>Level 3. Here, GSK3B is linked to neoplasm.