We collected pathological sections from 30 patients with laryngeal cancer, hypopharyngeal cancer, and 10 patients with vocal cord polyps, and immunohistochemical DAB staining was performed to detect the expression of GSK3B in these tissues.<h4>Results</h4>A total of 6163 differentially expressed genes were jointly identified between HNSC and control samples. This evidence concerns the gene GSK3B and laryngeal carcinoma.