NFKB1 and neoplasm: The examination of tumour cell proliferation and invasion was conducted using the following assays: CCK-8, colony formation, scratch assay, Co-immunoprecipitation (Co-IP) experiment, Immunohistochemistry (IHC) experiment and Transwell.<h4>Results</h4>NFIC binds to the promoter regions of OGN and PTEN and regulates their transcription, leading to increased expression of these two genes,while simultaneously limiting the expression of NF-κB, SHP2, p-SHP2, PI3K, AKT, Cyclin A1, Cyclin D1, MMP-3, and MMP-9.