<h4>Objective</h4>The objective of this study is to elucidate the mechanism by which NFIC exerts its regulatory influence over NF-κB/PTEN, with a view to gaining insight into the processes underlying the proliferation and invasion of glioma cells.<h4>Methods</h4>The interactions between genes in gliomas were predicted and verified through bioinformatics analysis. Here, PTEN is linked to central nervous system cancer.