APOL1 and chronic kidney disease: There was no association between individuals with APOL1-LR genotypes with M1 and protection against CKD or FSGS.<h4>Conclusions and relevance</h4>In this case-control study of 107 696 individuals, presence of an APOL1-HR genotype M1 was significantly associated with protection against kidney disease, suggesting that it may have a role as a genetic modifier.