Our study illustrates the importance of IFN-γ signaling in T cell-monocyte interaction in malaria-associated lung pathology, highlighting the complex and intricate immune network induced by the <i>Plasmodium</i> infection.IMPORTANCEMalaria-associated lung pathology is a common complication of malaria in adults and often occurs during or even after antimalarial treatment, and current evidence suggests that it is associated with cytokine imbalance and dysregulation of immune responses in the lungs. The gene discussed is IFNG; the disease is malaria.