Furthermore, the recurrence models developed mainly using pathomics were strongly accurate for predicting 1-year recurrence (AUC = 0.907 in training and 0.769 in validation).<h4>Conclusions</h4>Integrating pathomic features with clinical variables via machine learning enables robust pretreatment prediction of NAC efficacy and short-term recurrence in HR-positive, HER2-negative breast cancer. This evidence concerns the gene ERBB2 and breast carcinoma.