The <i>in vivo</i> analysis of peripheral blood mononuclear cells from individuals in a helminth/TB endemic region showed increased frequencies of CD38<sup>hi</sup>CD24<sup>hi</sup> B regulatory cells in helminth infected, and MZ B cells (IgM<sup>high</sup> unswitched B cells) in both helminth-infected and helminth/TB co-infected individuals.<h4>Conclusion</h4>ASC antigen exposure modulates T cell activation through dynamic regulation of the IL-15-pathway and STAT signaling. The gene discussed is IL15; the disease is tuberculosis.