Among younger individuals with severe CAD, intermediate monocyte subcluster iMo_HLA-DR<sup>int</sup>CCR2<sup>low</sup> was increased, whereas anti-inflammatory classical monocyte cMo_CD33<sup>hi</sup>CD163<sup>hi</sup>CXCR4<sup>+</sup> was reduced. This evidence concerns the gene CXCR4 and coronary artery disorder.