Interestingly, chemokine receptor expression also correlated with lipid parameters in older individuals where CCR6 expression on intermediate monocytes positively associated with HDL cholesterol and increased with CAD severity, whereas CXCR3 expression on classical monocytes declined with advancing CAD.<h4>Conclusions</h4>Aging is associated with distinct changes in monocyte chemokine receptor expression that relate to CAD severity. This evidence concerns the gene CXCR3 and coronary artery disorder.