Clinically, patients with IIH exhibit elevated inflammatory biomarkers (C-reactive protein, neuron-specific enolase, neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios), intrathecal immunoglobulin G (IgG) synthesis, and increased neurofilament light chain levels, consistent with combined immune activation and neuroaxonal stress. Here, ENO2 is linked to pseudotumor cerebri.