DMC-GF exerted dose-dependent inhibitory effects on GBM cell proliferation, migration and invasion and concurrently promoted apoptosis, as reflected by reduced Bcl-2 expression, activation of Bax/Caspase-3 and reversal of epithelial-mesenchymal transition (E-cadherin↑, N-cadherin↓, MMP-3↓). The gene discussed is BCL2; the disease is glioblastoma.